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Oxidized Cholesterol 27HC May Explain 3 Breast Cancer Mysteries



Oxidized cholesterol (concentrated in products containing eggs, processed meat, and parmesan cheese) has cancer-fueling estrogenic effects on human breast cancer.

Get the preface for Dr. Greger’s brand-new book, How Not to Diet, by subscribing to his free newsletter at https://nutritionfacts.org/subscribe.

The video I mentioned is How to Reduce Cholesterol Oxidation (https://nutritionfacts.org/video/how-to-reduce-cholesterol-oxidation/). For the role in Alzheimer’s disease see Oxidized Cholesterol as a Cause of Alzheimer’s Disease (https://nutritionfacts.org/video/oxidized-cholesterol-as-a-cause-of-alzheimers-disease/).

This is the 3rd in a 3-video series on cholesterol and cancer. In case you missed the first two: Eggs and Breast Cancer (http://nutritionfacts.org/video/eggs-and-breast-cancer) and Dietary Cholesterol and Cancer (http://nutritionfacts.org/video/dietary-cholesterol-and-cancer).

There’s all sorts of foods that can decrease breast cancer risk, though, and even improve survival. See, for example:
• Broccoli vs. Breast Cancer Stem Cells (https://nutritionfacts.org/video/broccoli-versus-breast-cancer-stem-cells/)
• Why Do Asian Women Have Less Breast Cancer? (https://nutritionfacts.org/video/why-do-asian-women-have-less-breast-cancer/)
• Flaxseeds & Breast Cancer Prevention (https://nutritionfacts.org/video/flaxseeds-breast-cancer-prevention/)
• Breast Cancer vs. Mushrooms (https://nutritionfacts.org/video/breast-cancer-vs-mushrooms/)
• Preventing Breast Cancer by Any Greens Necessary (https://nutritionfacts.org/video/preventing-breast-cancer-by-any-greens-necessary/)
• Which Dietary Factors Affect Breast Cancer Most? (https://nutritionfacts.org/video/Which-Dietary-Factors-Affect-Breast-Cancer-Most)
• How to Block Breast Cancer’s Estrogen-Producing Enzymes (https://nutritionfacts.org/video/How-to-Block-Breast-Cancers-Estrogen-Producing-Enzymes)
• Is Soy Healthy for Breast Cancer Survivors? (https://nutritionfacts.org/video/Is-Soy-Healthy-for-Breast-Cancer-Survivors)

Best way to get D? See The Best Way to Get Vitamin D: Sun, Supplements, or Salons? (https://nutritionfacts.org/video/the-best-way-to-get-vitamin-D-sun-supplements-or-salons) and The Risks and Benefits of Sensible Sun Exposure (https://nutritionfacts.org/video/the-risks-and-benefits-of-sensible-sun-exposure).

Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries and someone on the NutritionFacts.org team will try to answer it.

Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries. You’ll also find a transcript and acknowledgments for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics.

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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM

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37 comments

  1. Did you know we also have a podcast? New episodes come out every Thursday. Check it out and subscribe here: https://nutritionfacts.org/audio/ -NF Team

  2. Help us for beating PSSD , Please .

  3. 2 months ago I had a estrogen positive breast tumor removed. They wrote me a script for an estrogen blocker and I filled the prescription and looked up side effects. Absolutely, heck no, I will never take that debilitating pill! I did, by the way, have high cholesterol and had no idea how cholesterol effected the tumor. Thanks so much doctor for this info, this is an answer to prayer. Any other suggestions you may have to me keep stay clear of another tumor would be highly appreciated. 🙂

  4. "We know cholesterol CAN cause inflammation in our artery walls." False, eating carbohydrates causes cracks in your artery walls which afterwards cholesterol tries to fix, mixing carbs with foods rich in cholesterol will most likely give you a stroke.
    Being biased isn't gonna help the human race.
    Who gives a shit about vegans and who gives a shit about "meat eaters", you both are biased as fuck and I wouldn't take advice from a half dead zombie looking motherfucker.

  5. Been vegan a month. Dropped 20 pounds and my cholesterol dropped. Should of done this sooner. I’m 27 years old.

  6. "…27HC, a metabolite of cholesterol, can function as an
    estrogen…" (https://youtu.be/jG5tM2WwVjI?t=191)
    Wait a minute, can 27HC function as estrogen in males as well?
    Would that indicate a theoretical possibility that a high
    cholesterol intake may cause feminization?

    I feel that would be the final nail in the coffin for the common
    overstating of the impact of phyto-estrogens in soy.

  7. Great information! Thanks for doing the research and posting!!

  8. Cholesterol is the backbone structure on our cell walls and also for some transportation system in our blood between cells. It is definetely not harmful by just alone itself. By Oxidising cholesterol is completely different thing, my father had a cholesterol problem and he took some many drugs by doctors. And do you know it is bullshit!! Most of drugs in the market are not working, we are making drug companies more richer. So because we believe this, he started a perfect diet and also sport but not like gym its more about fast movements now he can control his cholesterol sorry oxidized cholesterol. I have a great source for this kind of diet and sport, let me know if anybody needs it.

  9. "OXIDIZED" cholesterol is what causes the damage >>> Limit the cholesterol and you limit the number of oxidized damages. Limited damages and your body can cope to heal itself. Severe damages and you reach the tipping point of no return.

    It's like swimming in a pool filled with sharks, but don't worry the sharks are not hungry. You are still better off swimming in a pool with no sharks.

  10. Deylan mebrusta – Grains should be thought of as a SURVIVAL food NOT a "health" food. Phytic acid in foods which both legumes AND GRAINS are LOADED with make absorption of nutrients MORE DIFFICULT which is a HUGE disadvantage. Needless to day, everyone know legumes are extremely difficult to digest – EVEN after cooking.

    Why fight it? Humans are frugivores. We have a SENSITIVE G.I. tract and the easiest and best way we can absorb the most nutrients the most easily is to eat a SPECIES APPROPRIATE DIET of RAW FRUIT AND RAW VEGETABLES.

    Sorry but the medical establishment is clueless about health. Any medical doctor should be the first to admit, they learn precious little about health in medical school.

    So Americans who are incapable of critical thinking should do themselves a favor and WAKE UP and look to those who HAVE not only studied health, but have also studied SCIENCE and have a PROVEN TRACK RECORD showing people with so called "incurable [by the medical profession] diseases" how to REVERSE those conditions and restore their robust health if they want to be healed… and stop wasting time with medical doctors who only know how to SUPPRESS problems with drugs (and exacerbate them) and spread inaccurate, incomplete information about food and health..

  11. Any opinion about this ?
    Rong Y, Chen L, Zhu T, et al. Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies.

  12. With all of your background knowledge, I would be very interested in a video about what studies say happens to your body when you go vegan. From a timeline perspective. Like after one week your cholesterol can be cut in half, or after three months your DNA can change. Does anyone else know of any resources like this?

  13. I'm getting the feeling that these studies are just paid advertisement for statins and junk food. Since eggs are the bad boys, this begs the question how oxidized is the LDL in eggs? Are free-range eggs better than factory eggs? You can take a hundred of these studies, mix them all up, and all they say is don't eat eggs, and go on being 300 pounds and take your statins, and you'll be fine.

  14. KETO … Make America fit again

  15. Would you please address this recent prospective case-control study using the EPIC cohort, which has conflicting results to previous studies:
    https://doi.org/10.1093/jnci/djy115

  16. Raw egg yolks and low heat pasteurized dairy don't contain oxidized cholesterol. Only processed (at very high temperatures for a long time) does. Especially when fried in polyunsaturated fats: https://www.researchgate.net/publication/233065216_Oxidation_of_Cholesterol_in_Foods_and_Its_Importance_for_Human_Health

  17. Extremely impressive research summary! Well done NF team!

  18. I thought that Staten drugs were not always affective. I bet if most people have the choice they would rather take the drug and keep their own crappy diet, just like my one family member who now has Parkinson’s, after taking statins for years and eating very high cholesterol.
    Every day I’m amazed that this information is out there, and no one knows about it! People get mad at me when I tell them. They get mad that there is a cure for the worst diseases! Can you imagine??

  19. Those of us who eat no animals are on zero cholesterol diets right? I eat no flesh, no eggs, and no dairy. I do consume some organic raw unfiltered honey stolen from local bees but they made it from plants and it is cholesterol free and of course I eat plants and fungi but don't use added oil at home only on rare occasion eating out. I might buy hashbrowns, vegie patties, or some other oil containing junk food maybe once a week tops but not every week. I'd like to do vegan pizza up to once a week if i could afford to splurge. Do any plant foods have or promote cholesterol? I'm just wondering if I did eat vegan junk food one day every week but ate a low fat whole food plant and fungi based no oil diet for six days is it okay to have that oily high fat junk food for one day every week? Or once every other week? Like do we have enough data currently to determine a safe limit for strict vegetarian junk food? I get that none is best but since I'm a pizza addict i need to know how often can i get away with eating one little frozen amys vegan pizza lol

  20. Would that make coconut oil evil again???

  21. I had very aggressive cancer 18 years ago and wasn't expected to survive. Maybe the vegan diet explains why I'm still here. They told me to eat lots of protein and eggs but I listened to Dr. McDougall instead.

  22. Apparently 12 people are still sold on the paleo bill of goods.

  23. One of the best videos yet. TFP!

  24. Cancer eats glucose and glutamine. Cut those out and cancer dies.

  25. Why not mention at the end of this video that we only get dietary cholesterol from animal products?

  26. Thank you Dr. Greger. GOD BLESS.🙂

  27. Please talk about Glycation. What if the whole "Cholesterol is bad" is mislabeled, and it's really the presence of damage Cholesterol via excess sugar consumption?

  28. I have been doing the research, watching the movies and videos, reading the books, eating the food, losing the weight, lowering my cholesterol and blood sugar, and generally, looking and feeling younger and healthier. And like many vegans, I can't stop telling people about the extraordinary benefits of a PBWF diet, including my wife, who hates me for it, and my parents, who are in their late 70s, on too many medications and would greatly benefit from it. Heck, my cousin is a perfusionist (he works on the heart surgery team), and he laughs at the idea. Clearly, the institutionalized bias makes it difficult to break through, and no one, literally no one, is financially incented to change that institutional bias. (Perhaps that would change with a single payer system.) My question is, how do we effect change beyond our own bodies? I think Nutritionfacts.org does great work, as do many others, but it is spitting into the wind. Should we begin suing doctors for medical malpractice or bringing class action lawsuits against the food companies? Once there is enough scientific evidence, should we not require caution labels on offending products: Warning, this tenderloin is known to cause cancer? Someone needs to be at the epicenter of this battle, and Dr. Greger is well positioned to help lead this charge. If you want to make a real difference, change the economics.

  29. Still never any answer about egg whiles. No cholesterol there. I get it's still an animal product, but surely a little egg white here or there is ok.

  30. Ways to reduce oxidative stress and oxidation. Consume more plant food, eat less carbs, exercise, get enough sleep, and have healthy supportive relationships and a purpose in life. I would also recommend reducing sugar and salt intake. Take green tea everyday. Eat broccoli sprouts, walnuts, and almonds everyday. Take a blueberry smoothie everyday with ground flaxseed powder added. Eat a salad with lunch and dinner. Tomatoes are high in antioxidants. Consume more beans.. kidney beans are #1 in antioxidants. Add mushrooms to your diet.. I suggest taking the 14 mushroom mix powder from mushroomharvest.com everyday (2 tsp). Don't forget to take Vitamin D, B12, and Selenium supplement. These will do for now.

  31. I went back to eating hard-boiled eggs, frying creates oxidized cholesterol and cancer-causing compounds.

  32. Podcast every thursday? Great!

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