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The Cholesterol Conundrum – and Root Cause Solution

A detailed analysis of Cholesterol Science using an Engineering Problem Solving approach. Included is a clear explanation of the Cholesterol Metabolic Processes, related Diseases, and most importantly a clear summary of the key risk factors and how they can be influenced by your genetic type and your dietary strategy. Please see Comment Section below for an index to the various content sections, so you can jump to the ones of most interest; for best understanding though, it should be watched sequentially. Produced for the benefit of all, and to encourage open scientific discourse on this important topic. Best Regards, Ivor.


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  1. The Cholesterol Myths by UffeRavnskov, MD, PhD

  2. Great to have such complexity refined, filtered, and delivered with charm. You are like a liver to academic research papers. Many thanks Ivor.

  3. This presentation was so helpful and well explained. Thank you!! 🙏🏻

  4. This needs to be a required class for everyone to get educated as well.

  5. He has good accent. Enough to sound good but still easy to understand.

  6. at 1:01:14 on the chart there is 26 pct CHo + SF – What the hell is SF?

  7. At 48:03, i don't quite understand how to interpret the graph or where i'm located on it. In what units is the axis at the bottom. And what does HDL= 2.20 mean?

  8. You mentioned that so far there has been no successful way to push up the amount of HDL. My question is does diet have any influence on the HDL level and if so what diet best supports HDL levels?

  9. Way cool information Ivor. Thanks so much for sharing. I am literally taking to heart.

  10. No one explained this subject better than Mr. Ivor and many thanks to him

  11. Valuable stats to note the percent cardiac events of high TG when LDL/HDL ratio is less than 5 vs greater that 5..The AHA says that TG of 100 is optimal without ref to the other ratio

  12. I'm 27 and I have the lowest body fat iv had in 12 years, daily intermittent fasting 16-8 sometimes 18-6, workout 3 days a week and eat LCHF on the weekends, try to eat low carb in the week too but sometimes its not possible, whatever fits the easiest I'm not super strict about it and I don't need to with my current metabolism. Ideally I would go full LCHF, its something to strive for in the future but not something I'm obsessed about atm. I feel optimal on LCHF after a meal whereas on my carb days I feel a little bit more shitty, more water retention resulting in higher weight and less lean look, dips 1-2 hours after meal and brain is impeded by the meal, thinking is not as fast and concentrated. Software developer so I notice the effects of diet on my thinking acutely.

    On the weekends I eat high fat bacon and eggs at 1pm as my first meal, 4-5 hours later next meal low in carbs, high in fat & protein, less cravings for a cigarette or junk food while on LCHF, I realized that my addictive habits were largely due to the effects carbohydrates that made me grab high stimulating foods (sugary) and cigarettes because of the stress induced from the cravings and over time associating cravings with the need for a smoke.

    I know smoking is bad, I don't do it regularly like I used to anymore, in time I will be able to drop it completely.

  13. really interesting lecture!

  14. 53:00 Priceless information! Thank you!

  15. 46:30 Excellent! I am going to show this to my doctor!

  16. I bet I have referred this video to 15 people! Many of them freaked out that their docs want them on statins for numbers in the 200's. I LOVE this one as it is understandable for most folks. Good job Ivor!

  17. This diet (ketogenic) works people. Here's my story…..

    I just got the results of my CAC (Coronary Artery Calcium) score test that I had done last Tuesday came back today. This test is the "GOLD STANDARD" as far as diagnosing your chances of having a future cardiac event, as it can actually see the disease happening in real time.

    It came back with a score of ZERO! Which basically means that this low carb HIGH FAT diet that I am on must really work. Some of the supplements I'm taking help too (like Fish oil), but nothing trumps the overall macro's of your diet.

    Keep in mind that:
    A: two and a half years ago I was about 100 pounds overweight. Not good for your heart,
    B: I had edema in my legs so badly that I couldn't stand for more than a few hours, and even sitting down hurt them. A sure sign of CVD. Lynn had even commented that she'd seen that level of edema in people in the nursing home that had CHF (congestive heart failure).
    C: I was having chest pains frequently.
    D: I had previously smoked 2+ packs a day for about 28 years (since age 19).
    E: My BP was around 168/96 (resting).. Just barely under stage 3 hypertension. Currently around 125/75 or less.
    F: Did I mention my family history of heart disease? My dad died before reaching 60, and my older brother Richard died suddenly at around age 60 (about 5.5 years ago) and he had a half dozen stents in him at the time (he was about my age when he had them put in).

    At age 50, I was a walking/talking heart attack just waiting to happen. I am living PROOF that a low carb HIGH FAT diet not only helps you to lose weight, but it is also the best diet for your heart. It has actually reversed a lot of the obvious cardiovascular problems I was having.

    I had tried to "reduce calories" and "eat right" by doing a "low fat" diet according to what the AMA and ADA recommend, as well as vigorous exercise 3 to 5 times a week (40+ minute intense workouts). After nearly two years, I lost almost no weight doing that crap. When I finally bitched to my Dr. (Susan Wasson in Osakis) that I was having zero progress, she merely looked at me and said "Oh, you're insulin resistant, do Atkins". I only wish that she had elaborated more on the diet than what she did. It took me another 6 months for me to finally start, but it paid off almost immediately, as I lost 30 pounds in 30 days.

    Of course my "friends" at that time did notice the weight loss, but admonished me that I was going to either have a stroke, a heart attack, or get colon cancer from eating all that protein, fat, & cholesterol. Basically a trifecta of fat induced death. Because that's what they'd heard, and then parroted back to me like mindless birds…. Of course one of them is still fat, and getting even fatter, and is having more and more medical problems. He's currently eating a wheat/gluten free high carb diet…

  18. With regard to increasing HDL at 31:19 , may I ask how products like Benecol are viewed? Grapevine seems unequivocal in their ability to lower LDL/promote HDL- fallacy? Thanks for any feedback!

  19. whiy don't you allow others to add subtitles to your videos..that would be great if the informatin could transcend english language

  20. Outstanding presentation. Medical community is still putting out the ridiculous blood test reports red flagging HDL as too high when its driving down the TG/HDL-c ratio which is clearly the BEST predictor of heart disease risk.

  21. Hello Ivor,
    I couldn'ti find the scientific article shown in minute 45 of your lecture about the Framingham Heart Study in the Journal of Cardiovascular medicine year 2011 that talks about the importance of HDL over LDL.

    ¿Could you send me the link to the article?
    I'm preparing a lecture on cholesterol in my hospital and it would be great to have the good sources of bibliography.

    Thanks a lot,
    You serve as a great inspiration

    Jorge García-Dihinx
    Pediatrician Hospital San Jorge, Huesca Spain
    Unit of gastroenterology and nutrition. Obesity Clinic for overweight children

  22. Great video Ivor. I’m slightly confused, I watched your talk on insulin resistance and understood that this was the real problem leading to heart disease and carbohydrate becoming an issue. How does insulin resistance tie in with the small dense LDL explanation you spoke of? Does small dense LDL still occur if someone is insulin sensitive, or does the person have to be insulin resistant for it to occur and become problematic?
    Am I correct in understanding that glucose takes a different pathway when a person is insulin sensitive and not generate the small dense LDL?
    Hope this makes sense! Thanks

  23. just got my results (bad, with high TG and low HDL), My Doc surprised me by saying I must go on LCHF diet and referred me to watch your video among other things and no meds prescribed. This is really helpful. A big eye-opener for me. Thank you.

  24. what is the title of the study referenced on the slide at 48' 11" and what year, Volume and Number is the study? It is mis labled on the slide as V00 and N00. Thanks.

  25. Thanks Ivor, a big fan and agree, since I think that Dr. Steven Gundry also points all this out with his "The Plant Paradox" and the Even the USDA data support this, i.e. in 1900 our diet was 10% refined carbs, today (2010) 63%. This 63% represents actually “Dietary Intake”, with the balance being Proteins and Fats. Our position should be "Returning Humans to a Normal Carb Diet", and would then guess that Insulin Resistance and the many issues would go away – and most Man-Made diseases would then go away – Never in history did humans eat any appreciable levels of carbohydrates this is something "New" and "Non-Seasonal".
    http://www.70GoingOn100.com the Centenarian Diet, or maybe 128, the Hayflick limit, … or if a Ray Kurzweil fan then this is a Moot Point …

  26. 31:00 So if I'm understanding this. HDL is probably onboarding antioxidants to LDL in addition to exchanging triglycerides for cholesterol. So LDLs that have regular interaction with HDL, increase size (cholesterol count) and are oxidizing resistant. LDLs that have no interactions with HDL stay small (no increase in cholesterol count) and dense and have no resistance to oxidation. Is this the mechanism for small dense bad LDL?

  27. Watching this in stages , Love the delivery and want to take everything in , Doc is giving me "Im gonna die soon cause my LDL is high " Even though Triggs and HDL are very good . Thanks for all your hard work Ivor

  28. Thank you so much for this! I would be very interesting and much appreciated if you could point out where in the system ApoE4 causes trouble. I'm trying to wrap my head about WHY ApoE4 is a risk factor (if it is).

  29. Excellent content!

  30. I want to marry you! Hahaha! Just kidding! Aside from being delightfully genius you've a great personality. What an EXCELLENT presentation. I'm in the same boat! I've been following the general guidelines too for a few decades only to end up sick! Now I'm on to the misinformation and I've lost 7 kg. I definitely have more energy- I'll be checking my labs next month- so… I'm excited and hopeful! Thank you!!!

  31. Closed caption help[ with hearing impaired.

  32. You didn't address Lp(a). Its been recently stated that high levels are an independent causation of CHD. If you have low Lp(a) but high trigs, small LDL particles and LDL-P, does the low Lp(a) level attenuate the overall risk of CHD?

  33. 81:00 Quiz time is win.

  34. One of the best and the clearest explanation on cholesterol I've ever seen.
    Amazing work.

  35. A very clear and interesting presentation. I used to follow a very low fat diet. Then the first time I had my lipids profile done, although the Dr. said all was good, I checked the ratios online and they were marginal. So, I checked the web and switched to include more "healthy fats" (not saturated), and increased exercising. The ratios improved dramatically.
    More recently I saw the documentary 'Cowspiracy' on Netflix, then originally for ethical /environmental reasons I started transitioning to a whole food plant based diet. I'm wondering how this compares to the higher protein/fat diet advocated here. It sounds like Mr. Cummins also favors whole plant food along with additional fat, from the comment at the end. I wonder if he did eat these healthy foods previously before changing his diet? Is it possible that his improvements could be attributed to increasing consumption of healthy plants and fiber?
    Most of the figures shown compare high carb to low carb, but don't specify what kind of carbs they are. If it's refined carbs then the comparison is between a bad carb diet and less bad carbs. That would make the higher fat diet look good, whether or not it was superior to a diet of whole foods with more carbs. Within the context of high fiber /whole plant foods I'd like to see a study comparing more saturated fat, unsaturated fat, and low fat. Protein I believe also generates high insulin, which should be of concern to this discussion.
    I think one experiment cited toward the end included low and high glycemic diets, so perhaps I should look there to see if it elucidates my concerns, but still that's only one experiment.

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